. "15859344"^^ . "COMMD1"@cs . . . . . . . . . . . . . "COMMD1"@cs . "COMMD1 (copper metabolism gene MURR1 domain containing protein 1), t\u00E9\u017E MURR1, je COMMD protein, kter\u00FD ovliv\u0148uje NF-\u03BAB signalizaci svou vazbou na chromatin v j\u00E1d\u0159e, hraje v\u0161ak tak\u00E9 roli v regulaci metabolismu m\u011Bdi (mutace COMMD1 zp\u016Fsobuje m\u011B\u010Fovou toxik\u00F3zu ps\u016F). Z\u0159ejm\u011B interaguje s cullin-RING ubikvitin lig\u00E1zov\u00FDm komplexem ECS (Elongins B/C, Cullin 2/5, SOCS). Starokadomskyy et al."@cs . "1047738"^^ . . . . "3209"^^ . "COMMD1 (copper metabolism gene MURR1 domain containing protein 1), t\u00E9\u017E MURR1, je COMMD protein, kter\u00FD ovliv\u0148uje NF-\u03BAB signalizaci svou vazbou na chromatin v j\u00E1d\u0159e, hraje v\u0161ak tak\u00E9 roli v regulaci metabolismu m\u011Bdi (mutace COMMD1 zp\u016Fsobuje m\u011B\u010Fovou toxik\u00F3zu ps\u016F). Z\u0159ejm\u011B interaguje s cullin-RING ubikvitin lig\u00E1zov\u00FDm komplexem ECS (Elongins B/C, Cullin 2/5, SOCS). Starokadomskyy et al. spekuluj\u00ED, \u017Ee COMMD1 ve vazb\u011B s proteinem CCDC22 stimuluje cullin-RING ubiquitin lig\u00E1zy t\u00EDm, \u017Ee blokuje jejich inhibitor CAND1. V d\u016Fsledku doch\u00E1z\u00ED z\u0159ejm\u011B k aktivaci NF-\u03BAB.Vyjma CCDC22 tak\u00E9 asociuje a CCDC93 a spoluvytv\u00E1\u0159\u00ED s nimi tzv. \u201ECCC komplex\u201C. Ten je schopen se v\u00E1zat na WASH komplex na \u010Dasn\u00FDch endozomech a regulovat transport ATP7A transport\u00E9ru m\u011Bdi."@cs . . "21"^^ . . . . . . .