. "cystick\u00E9 fibr\u00F3ze"@cs . "cystickou fibr\u00F3zou"@cs . . . . . "cystickou fibr\u00F3zu"@cs . . "Cystick\u00E1 fibr\u00F3za"@cs . . "3915"^^ . "2009"^^ . . "E84." . "295301"^^ . . . "fibrotick\u00FDm"@cs . . . "cystick\u00E9 fibr\u00F3zy"@cs . "cystick\u00E1 fibr\u00F3za"@cs . . . "Cystick\u00E1 fibr\u00F3za (CF) neboli mukoviscid\u00F3za je lidsk\u00E9 geneticky podm\u00EDn\u011Bn\u00E9 onemocn\u011Bn\u00ED, kter\u00E9 postihuje p\u0159ev\u00E1\u017En\u011B d\u00FDchac\u00ED a tr\u00E1vic\u00ED soustavu. Jde o autozom\u00E1ln\u00ED recesivn\u00ED vrozen\u00E9 onemocn\u011Bn\u00ED zp\u016Fsoben\u00E9 mutac\u00ED genu produkuj\u00EDc\u00EDho protein CFTR (anglicky Cystic fibrosis transmembrane conductance regulator). Jedn\u00E1 se o gen ulo\u017Een\u00FD na dlouh\u00E9m ram\u00E9nku 7. chromozomu. Gen k\u00F3duje protein, kter\u00FD je kl\u00ED\u010Dov\u00FD pro chloridov\u00FD ABC transport\u00E9r na bun\u011B\u010Dn\u00E9 membr\u00E1n\u011B.Jm\u00E9no cystick\u00E1 fibr\u00F3za se vztahuje k charakteristick\u00E9 fibr\u00F3ze a cyst\u00E1m, kter\u00E9 vznikaj\u00ED p\u0159i nemoci ve slinivce.L\u00E9\u010Dba se v sou\u010Dasnosti soust\u0159e\u010Fuje zejm\u00E9na na l\u00E9\u010Dbu d\u00FDchac\u00EDho \u00FAstroj\u00ED \u2013 inhalace, fyzioterapie, antibiotika. Nemocn\u00ED u\u017E\u00EDvaj\u00ED tr\u00E1vic\u00ED enzymy v kapsl\u00EDch, tedy na odstra\u0148ov\u00E1n\u00ED d\u016Fsledk\u016F onemocn\u011Bn\u00ED. Jeho p\u0159\u00ED\u010Dina je l\u00E9\u010Diteln\u00E1, ale zat\u00EDm nevyl\u00E9\u010Diteln\u00E1.V \u010Cesku se ka\u017Edoro\u010Dn\u011B s touto nemoc\u00ED narod\u00ED 1 d\u00EDt\u011B z p\u0159ibli\u017En\u011B 2500 a\u017E 3000 narozen\u00FDch d\u011Bt\u00ED, co\u017E je celkov\u011B okolo 40 a\u017E 50 d\u011Bt\u00ED v populaci. Diagnostikovan\u00E1 nemoc b\u00FDv\u00E1 ale jen zhruba u poloviny z nich. Polovina nemocn\u00FDch se dnes v \u010Cesk\u00E9 republice do\u017E\u00EDv\u00E1 alespo\u0148 32 let. P\u0159edpokl\u00E1d\u00E1 se, \u017Ee ka\u017Ed\u00FD 25. \u010Dlov\u011Bk v populaci je p\u0159ena\u0161e\u010Dem posti\u017Een\u00E9ho genu, ale jeliko\u017E m\u00E1 jednu kopii po\u0161kozenou a druhou v po\u0159\u00E1dku, onemocn\u011Bn\u00ED se u n\u011Bho neprojevuje."@cs . . . "mukoviscid\u00F3zou"@cs . "Cystick\u00E1 fibr\u00F3za (CF) neboli mukoviscid\u00F3za je lidsk\u00E9 geneticky podm\u00EDn\u011Bn\u00E9 onemocn\u011Bn\u00ED, kter\u00E9 postihuje p\u0159ev\u00E1\u017En\u011B d\u00FDchac\u00ED a tr\u00E1vic\u00ED soustavu. Jde o autozom\u00E1ln\u00ED recesivn\u00ED vrozen\u00E9 onemocn\u011Bn\u00ED zp\u016Fsoben\u00E9 mutac\u00ED genu produkuj\u00EDc\u00EDho protein CFTR (anglicky Cystic fibrosis transmembrane conductance regulator). Jedn\u00E1 se o gen ulo\u017Een\u00FD na dlouh\u00E9m ram\u00E9nku 7. chromozomu."@cs . . . . . . . "26"^^ . . . . . "Cystick\u00E9 fibr\u00F3zy"@cs . . . "D003550"@cs . . . . . "D003550" . . "Cystick\u00E1 fibr\u00F3za"@cs . . "Cystick\u00E1 fibr\u00F3za"@cs . . . "16145723"^^ . . "cystickou fibrosu"@cs . . . . . . .