. . "Multivezikul\u00E1rn\u00ED t\u011Bl\u00EDsko (z angl. multivesicular body - MVB) je typ vnitrobun\u011B\u010Dn\u00E9ho v\u00E1\u010Dku vyskytuj\u00EDc\u00EDho se u v\u011Bt\u0161iny prostudovan\u00FDch eukaryotick\u00FDch bun\u011Bk, kter\u00FD vznik\u00E1 zr\u00E1n\u00EDm \u010Dasn\u00FDch endoz\u00F3m\u016F a tzv. invaginac\u00ED v\u00E1\u010Dk\u016F dovnit\u0159 v\u00E1\u010Dk\u016F samotn\u00FDch (vznikaj\u00ED tzv. intralumin\u00E1ln\u00ED v\u00E1\u010Dky). V endocytick\u00E9m transportu je MVB na pomez\u00ED mezi stadiem \u010Dasn\u00E9ho endoz\u00F3mu a pozdn\u00EDho endoz\u00F3mu - postupn\u011B se zbavuje povrchov\u00FDch molekul typick\u00FDch pro plazmatickou membr\u00E1nu \u010Di pro \u010Dasn\u00E9 endoz\u00F3my a naopak v n\u011Bm p\u0159ib\u00FDvaj\u00ED nap\u0159. lysozom\u00E1ln\u00ED hydrol\u00E1zy typick\u00E9 pro pozd\u011Bj\u0161\u00ED stadia.V procesu invaginace v\u00E1\u010Dk\u016F dovnit\u0159 v\u00E1\u010Dku samotn\u00E9ho, a tedy ve vzniku MVB, hraj\u00ED kl\u00ED\u010Dovou roli proteinov\u00E9 komplexy ESCRT (protein Hrs a posl\u00E9ze komplexy ESCRT-I, ESCRT-II, ESCRT-III). Jsou zodpov\u011Bdn\u00E9 zejm\u00E9na za to, aby se do intralumin\u00E1ln\u00EDch v\u00E1\u010Dk\u016F dost\u00E1valy ubiquitinylovan\u00E9 receptory ur\u010Den\u00E9 k degradaci. Tyto receptory jsou rozezn\u00E1ny Hrs a invaginov\u00E1ny dovnit\u0159 vznikaj\u00EDc\u00EDho MVB. V typick\u00E9m p\u0159\u00EDpad\u011B jsou tyto vnit\u0159n\u00ED v\u00E1\u010Dky degradov\u00E1ny po f\u00FAzi MVB s lysoz\u00F3my, ale v n\u011Bkter\u00FDch p\u0159\u00EDpadech mohou splynout vn\u011Bj\u0161\u00ED membr\u00E1ny MVB s plazmatickou membr\u00E1nou a vnit\u0159n\u00ED intralumin\u00E1ln\u00ED v\u00E1\u010Dky se uvoln\u00ED jako tzv. exoz\u00F3my."@cs . . . . . . . . "Multivezikul\u00E1rn\u00ED t\u011Bl\u00EDsko"@cs . . "21"^^ . "14153023"^^ . . . . "1233299"^^ . . "Multivezikul\u00E1rn\u00ED t\u011Bl\u00EDsko (z angl. multivesicular body - MVB) je typ vnitrobun\u011B\u010Dn\u00E9ho v\u00E1\u010Dku vyskytuj\u00EDc\u00EDho se u v\u011Bt\u0161iny prostudovan\u00FDch eukaryotick\u00FDch bun\u011Bk, kter\u00FD vznik\u00E1 zr\u00E1n\u00EDm \u010Dasn\u00FDch endoz\u00F3m\u016F a tzv. invaginac\u00ED v\u00E1\u010Dk\u016F dovnit\u0159 v\u00E1\u010Dk\u016F samotn\u00FDch (vznikaj\u00ED tzv. intralumin\u00E1ln\u00ED v\u00E1\u010Dky)."@cs . . "Multivezikul\u00E1rn\u00ED t\u011Bl\u00EDsko"@cs . "multivezikul\u00E1rn\u00EDch t\u011Bl\u00EDsek"@cs . . . . . . "multivezikul\u00E1rn\u00ED t\u011Bl\u00EDsko"@cs . . "2278"^^ . . . . . .