. . . . "nikotinov\u00FDm acetylcholinov\u00FDm receptor\u016Fm"@cs . . . . . "Nicotinic acetylcholine"@cs . . "2841"^^ . . . "Nikotinov\u00FD acetylcholinov\u00FD receptor"@cs . "nikotinov\u00FDch cholinergn\u00EDch receptor\u016F"@cs . . . . "nikotinov\u00FDch acetylcholinov\u00FDch receptor\u016F"@cs . . . . . . . . . . "nikotinov\u00FD acetylcholinov\u00FD receptor"@cs . "nikotinov\u00E9ho acetylcholinov\u00E9ho receptoru"@cs . . "640964"^^ . . . . . "nikotinov\u00E9"@cs . "nikotinov\u00E9 acetylcholinov\u00E9 receptory"@cs . "Nikotinov\u00FD acetylcholinov\u00FD receptor (NAChR) je ligandem ovl\u00E1dan\u00FD iontov\u00FD kan\u00E1l ve form\u011B pentameru lokalizovan\u00FD na postsynaptick\u00E9 membr\u00E1n\u011B. Jeho endogenn\u00EDm agonistou je acetylcholin, exogenn\u00EDm pak nikotin. Vazba acetylcholinu vyvol\u00E1 otev\u0159en\u00ED kan\u00E1lu a tok kationt\u016F skrze kan\u00E1l, co\u017E zp\u016Fsob\u00ED depolarizaci postsynaptick\u00E9 membr\u00E1ny. Reverzibiln\u00EDm blok\u00E1torem tohoto receptoru je \u0161\u00EDpov\u00FD jed kurare, ireverzibiln\u00EDmi blok\u00E1tory jsou nap\u0159. \u03B1-bungarotoxin (v jedu kor\u00E1lovcovit\u00FDch had\u016F rodu Bungarus) a najatoxin (v jedu had\u016F rodu Naja \u2013 kobra).Existuj\u00ED dva hlavn\u00ED typy t\u011Bchto receptor\u016F, li\u0161\u00EDc\u00ED se sv\u00FDmi podjednotkami \u2013 nervov\u00FD typ NN ve vegetativn\u00EDch gangli\u00EDch, a svalov\u00FD typ NM na nervosvalov\u00E9 plot\u00E9nce. V CNS existuj\u00ED dv\u011B hlavn\u00ED varianty (dle obsa\u017Een\u00FDch podjednotek): \u03B14beta2 a a \u03B17, p\u0159i\u010Dem\u017E antagonistou: je \u03B1-bungarotoxin (had\u00ED jed). Nikotin desenzitizuje a inaktivuje NAChR, ale na rozd\u00EDl od acetylcholinu nen\u00ED hydrolyzov\u00E1n."@cs . "Nikotinov\u00FD acetylcholinov\u00FD receptor (NAChR) je ligandem ovl\u00E1dan\u00FD iontov\u00FD kan\u00E1l ve form\u011B pentameru lokalizovan\u00FD na postsynaptick\u00E9 membr\u00E1n\u011B. Jeho endogenn\u00EDm agonistou je acetylcholin, exogenn\u00EDm pak nikotin. Vazba acetylcholinu vyvol\u00E1 otev\u0159en\u00ED kan\u00E1lu a tok kationt\u016F skrze kan\u00E1l, co\u017E zp\u016Fsob\u00ED depolarizaci postsynaptick\u00E9 membr\u00E1ny. Reverzibiln\u00EDm blok\u00E1torem tohoto receptoru je \u0161\u00EDpov\u00FD jed kurare, ireverzibiln\u00EDmi blok\u00E1tory jsou nap\u0159."@cs . . . . "16492797"^^ . . "Nikotinov\u00FD acetylcholinov\u00FD receptor"@cs . . . . . . "nikotinov\u00E9 cholinergn\u00ED receptory"@cs . "33"^^ .