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<http://cs.dbpedia.org/resource/Perifern\u00ED_tolerance>	<http://www.w3.org/2000/01/rdf-schema#comment>	"Perifern\u00ED tolerance je \u010D\u00E1st imunologick\u00E9 tolerance, kter\u00E1 funguje na imunologick\u00E9 periferii (pot\u00E9, co lymfocyty opust\u00ED prim\u00E1rn\u00ED imunologick\u00E9 org\u00E1ny). Hlavn\u00EDm c\u00EDlem perifern\u00ED tolerance je zajistit aby auto-reaktivn\u00ED T a B lymfocyt\u016F, kter\u00E9 unikly centr\u00E1ln\u00ED toleranci, nezp\u016Fsobily autoimunitn\u00ED onemocn\u011Bn\u00ED. Mezi hlavn\u00ED mechanismy perifern\u00ED tolerance pat\u0159\u00ED: ignorace antigenu, indukovan\u00E1 anergie T bun\u011Bk, klon\u00E1ln\u00ED delece T bun\u011Bk a jejich konverze na regulatorn\u00ED T bu\u0148ky (Treg)."@cs .
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<http://cs.dbpedia.org/resource/Perifern\u00ED_tolerance>	<http://dbpedia.org/ontology/abstract>	"Perifern\u00ED tolerance je \u010D\u00E1st imunologick\u00E9 tolerance, kter\u00E1 funguje na imunologick\u00E9 periferii (pot\u00E9, co lymfocyty opust\u00ED prim\u00E1rn\u00ED imunologick\u00E9 org\u00E1ny). Hlavn\u00EDm c\u00EDlem perifern\u00ED tolerance je zajistit aby auto-reaktivn\u00ED T a B lymfocyt\u016F, kter\u00E9 unikly centr\u00E1ln\u00ED toleranci, nezp\u016Fsobily autoimunitn\u00ED onemocn\u011Bn\u00ED. Mezi hlavn\u00ED mechanismy perifern\u00ED tolerance pat\u0159\u00ED: ignorace antigenu, indukovan\u00E1 anergie T bun\u011Bk, klon\u00E1ln\u00ED delece T bun\u011Bk a jejich konverze na regulatorn\u00ED T bu\u0148ky (Treg). T bu\u0148ky, kter\u00E9 jsou tak\u00E9 generov\u00E1ny b\u011Bhem negativn\u00ED selekce, d\u00E1le tlum\u00ED efektorov\u00E9 funkce konven\u010Dn\u00EDch lymfocyt\u016F . B bun\u011B\u010Dn\u00E1 tolerance je m\u00E9n\u011B prostudov\u00E1na a nejsp\u00ED\u0161e je do zna\u010Dn\u00E9 m\u00EDry zaji\u0161t\u011Bna selekc\u00ED T bun\u011Bk, jeliko\u017E T bu\u0148ky pot\u0159ebuj\u00ED T bun\u011B\u010Dnou pomoc pro plnou maturaci."@cs .
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