. "sirtuin"@cs . . . "Sirtuiny (SIR \u010Di Sir2 proteiny) p\u0159edstavuj\u00ED skupinu enzym\u016F (ze skupiny NAD+-z\u00E1visl\u00FDch deacetyl\u00E1z), kter\u00E9 odstra\u0148uj\u00ED acetylov\u00E9 a dal\u0161\u00EDch kyselinov\u00E9 zbytky z modifikovan\u00E9 aminokyseliny lysin a reguluj\u00ED t\u00EDm \u0161irok\u00E9 spektrum bun\u011B\u010Dn\u00FDch pochod\u016F, zejm\u00E9na souvisej\u00EDc\u00EDch s bun\u011B\u010Dnou energetikou a homeost\u00E1zou. Sirtuiny byly nalezeny t\u00E9m\u011B\u0159 u v\u0161ech skupin \u017Eiv\u00FDch organism\u016F, a to v\u010Detn\u011B n\u011Bkter\u00FDch vir\u016F; savci maj\u00ED 7 r\u016Fzn\u00FDch sirtuin\u016F a tyto enzymy tak p\u0159edstavuj\u00ED prot\u011Bj\u0161ek k Zn2+-z\u00E1visl\u00FDm deacetyl\u00E1z\u00E1m.Sirtuiny se \u010Dasto anga\u017Euj\u00ED p\u0159i sn\u00ED\u017Een\u00ED p\u0159\u00EDjmu potravy, takzvan\u00E9 kalorick\u00E9 restrikci. Za t\u011Bchto stav\u016F doch\u00E1z\u00ED k masivn\u00ED deacetylaci protein\u016F v bu\u0148k\u00E1ch. Sirtuiny z\u0159ejm\u011B takto pom\u00E1haj\u00ED spou\u0161t\u011Bt obrannou reakci proti stresov\u00E9 situaci vyvolan\u00E9 nedostatkem potravy. N\u011Bkter\u00E9 studie ukazuj\u00ED, \u017Ee sirtuiny se \u00FA\u010Dastn\u00ED kontroly d\u00E9lky \u017Eivota (my\u0161i s nefunk\u010Dn\u00EDmi n\u011Bkter\u00FDmi sirtuiny maj\u00ED krat\u0161\u00ED \u017Eivot). Prob\u00EDh\u00E1 intenzivn\u00ED hled\u00E1n\u00ED aktiv\u00E1tor\u016F sirtuin\u016F (z\u0159ejm\u011B mezi n\u011B pat\u0159\u00ED nap\u0159. resveratrol), je\u017E by mohly m\u00EDt pozitivn\u00ED \u00FA\u010Dinky na d\u00E9lku a kvalitu \u017Eivota."@cs . . . . . . . . . . . . . "Sirtuiny (SIR \u010Di Sir2 proteiny) p\u0159edstavuj\u00ED skupinu enzym\u016F (ze skupiny NAD+-z\u00E1visl\u00FDch deacetyl\u00E1z), kter\u00E9 odstra\u0148uj\u00ED acetylov\u00E9 a dal\u0161\u00EDch kyselinov\u00E9 zbytky z modifikovan\u00E9 aminokyseliny lysin a reguluj\u00ED t\u00EDm \u0161irok\u00E9 spektrum bun\u011B\u010Dn\u00FDch pochod\u016F, zejm\u00E9na souvisej\u00EDc\u00EDch s bun\u011B\u010Dnou energetikou a homeost\u00E1zou."@cs . "Sirtuin"@cs . . . "17"^^ . "13686026"^^ . . "911396"^^ . . "2541"^^ . . . . . .